Under different estimates, about 8.7% of men deal with chronic prostatitis. Speaking about the chronic pelvic pain syndrome, it is experienced in 90% of prostatitis cases. Hence, these conditions are closely interconnected.
Tadalafil used together with the antibiotics for prostate inflammation curing promotes faster improvements and symptoms diminishment compared to the traditional therapy of the disease. Based on the results of the study held by the South Korean scientists, Tadalafil 5mg used together with levofloxacin (which is an antibiotic) on a daily basis for 6 weeks in a row significantly improves the chronic prostatitis symptom index and International Prostate Symptom Score. Both variables were used for the evaluation of the drug’s efficacy in 86 male patients taking part in the survey.
Chronic prostatitis/chronic pelvic pain manifestations and causes of appearance
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) induce the symptoms similar to the bacterial infection of the prostate. However, if with the letter the cause is obvious – bacteria, the nature of the first one is not so clear. Yet, what may raise the risks of getting CP/CPPS?
The probable triggers of the disease are the following:
- Microorganisms causing some sexually transmitted disease (e.g. chlamydia);
- Autoimmune illness, which affects the prostate;
- Irritation of the organ by the urine stasis;
- Abnormalities in the functioning of nerves and muscles.
To the major signs of the chronic pelvic pain syndrome/chronic prostatitis belong:
- Pain and burning when passing the urine and ejaculating;
- Urgency for urination;
- No feeling of the bladder emptiness even after the urination;
- Pain sensations spreading to the testicles, perineum, upper pubic area, lower abdomen, and back.
How does Tadalafil work for chronic prostatitis/chronic pelvic pain syndrome?
Prostatitis is an inflammatory ailment regardless of the cause. So, how can Tadalafil, which is a PDE-5 inhibitor, help to cope with the core of the issue?
Getting into the blood flow, Tadalafil triggers the production of nitric oxide, which in its turn stimulates the relaxation of the blood-vessel-walls and the smooth muscles of the prostate. As a result, the circulation of blood in the area gets better. Hence, it is much easier for the antibiotic to reach the target. Besides, an improved inflow and outflow of blood promote a better withdrawal of the inflammatory products from the organ.
Besides, Tadalafil has proven to be highly efficacious in the improvement of the lower urinary tract symptoms, which are characteristic of CPPS/CP. In the study conducted by the scientists of the University of Western Ontario, Canada once daily intake of 5mg of Tadalafil considerably improved all the indexes and scores used for the evaluation of the result. Furthermore, the incidence of negative reactions was very low.
The safety of Tadalafil intake for CP/CPPS
As the period of treatment with Tadalafil may be rather durable, it is natural to question its long-term safety. In fact, this question has already been studied in an open-label study involving 472 participants. Two groups, each of them comprising 234 and 238 people, took the drug for one and two years respectively. The results of the study claim that only 5% of the men experienced some light side effects. The most frequent of them were headaches, back pain, stomach upset, and nasal congestion. Serious adverse effects didn’t take place.