Silagra – Generic Sildenafil By Cipla Ltd.

Silagra tablets to treat erectile dysfunction

Erectile dysfunction drug called Silagra is a convenient and effective medication on the basis of sildenafil citrate. Silagra is produced by Cipla Ltd., an Indian pharmaceutical company with a universally recognized name whose history goes back to 1935. The standards of manufacture are controlled by the regulatory authorities, which guarantees high quality of used materials and techniques.

How Silagra helps to keep impotence in check

What is erectile dysfunction? It is a lack of ability to attain and/or maintain the hardness of the penis sufficient for sexual intercourse. It may be recurrent or occasional. Silagra brings back this ability, with some additional benefits:

• shortened recovery time between ejaculations
• a significant boost for sexual stamina
• better control over ejaculation
• alleviated performance anxiety
• increased satisfaction from sexual action
• overall benefits for sexual health on different levels

Silagra contains sildenafil citrate, which is a vasoactive agent improving the blood circulation in the smooth muscles of the penis. Thanks to this property, Silagra provides excellent results in ED management; these results are reflected in numerous studies, for example, the study performed at the Department of Surgery, Division of Urology, the University of North Carolina at Chapel Hill, by Dr. Culley C Carson and his colleagues. In the course of this study, men taking sildenafil were asked to estimate the benefits of the drug based on several criteria. In the course of the long-term use of sildenafil, more than 95% of the participants reported being satisfied with the received treatment.

Silagra dose and posology (dosing schedule)

Silagra is taken on demand, before planned sexual intercourse, which adds an extra layer of convenience to its use. The general rule is to take sildenafil pills 60 minutes prior to having sex, and this makes sense, as the drug reaches its peak concentration an hour after the intake. However, this study shows that 71% of users start experiencing the onset of effects already after 27 minutes, and 82% – after 45 minutes.

Silagra contains sildenafil 100mg, a dose that is considered to be maximal for safe use in different patient populations. The initial dose may be smaller; sildenafil 50mg is a median dose that can be stepped up in case your results are not optimal. The doctor’s opinion is required to prescribe Silagra and approve the dose.

How long does Silagra effect last?

Silagra effects last around 4 hours, but in many cases the postdose efficacy can be experienced 8 hours after you took the drug. What does it depend on? First of all, it depends on your current health condition, the severity of erectile dysfunction Silagra is used to treat, the last meal (if it was high on fat, the effect duration will be shorter and less pronounced), and individual response.

What if my dose is not effective?

According to Dr. Andrew R McCullough (Department of Urology, New York University Medical Center, New York), it is important to make sure that you take sildenafil pills correctly and based on prescriber’s instructions, use a correct dose, and take Silagra tablets on an empty stomach or after a light meal. Also, the same researchers established that the optimal number of intakes required to estimate patient reponse is 8 Silagra pills taken on separate days. Why is that so? The explanation is that sildenafil effects are accumulative and user response tends to improve with continued use of erectile health products, while side effects become milder or disappear.

Taking instructions

Swallow Silagra tablets with as much water as you feel comfortable with, without chewing or breaking the pills in your mouth. Avoid grapefruit or grapefruit juice, and alcohol when taking Silagra to avoid severe side effects.

Side effects list and management

Silagra side effects are not bothersome or persistent in nature, but in case they intensify, talk to your doctor about adjusting the dose. The most common side effects of Silagra are:

• headache
• flushing
• rhinitis
• sinusitis
• stomach upset

However, there are some adverse that you need to carefully watch out for. For instance, the reason to seek help urgently is difficulty breathing, increased heartbeat rate, swelling of the face, lips or tongue, and erections that do not subside in 4 hours or feel painful.

Silagra drug interactions

If you are taking other health products, you should give the full list to the prescriber. Silagra is incompatible with nitrate-based drugs against chest pain, drugs for fungal infections, HIV/AIDS, some antibiotics, other sexual health drugs for ED, and some others.

If you have other health condition

Tell the doctor about your current health condition. Silagra should not be used if you have the following:

• Retinitis pigmentosa, NAION
• Sickle cell disease, leukemia, hemorrhage disorders
• Peyronie’s disease, priapism
• Stomach ulcer, duodenum ulcer
• Kidney failure
• Liver dysfunction
• Heart disease
• Low blood pressure

Silagra price guide for a frugal shopper

Silagra is available at online pharmacies, which are not your first choice if you need your refill on the same day. If, on the other hand, you are willing to wait for up to two weeks, you will have meaningful benefits in savings: the drug price list in e-drugstores is up to 60% lower according to the WHO report. And for specific populations, such as patients requiring home care assistance or those living in remote areas, mail-ordering Silagra tablets is the only option.

The average Silagra price is 0.86 per pill – a price that can go down even more if you order bigger packages. Online pharmacy chosen with care can give unbeatable benefits of significant savings, confidentiality, and informativity. Do not forget that a doctor’s prescription is required to import your order in the U.S.

 

Sildenafil And How It Works

Silagra drug class: inhibitors of PDE5

The active substance in Silagra is sildenafil citrate, a molecule that has a powerful erectogenic action. The class of drugs sildenafil belongs to is called PDE5 inhibitors. PDE5 stands for something called ”phosphodiesterase type 5”, and this is the name of the substance that has several functions in the body related to transmitting signals along the nerve pathways.

What is the role of PDE5 in the erectile mechanism? This enzyme is responsible for the relaxation and contraction of the penile smooth musculature. For an erection to be attained, PDE5 needs to be blocked. Sildenafil is capable of blocking PDE5 by regulating the levels of cGMP (cyclic guanosine monophosphate) and increasing the level of NO (nitric oxide) in the smooth muscles.

The three structures in the shaft of the penis, two cavernous bodies and a spongeous body, are built up by smooth muscle: when these muscles relax, they absorb the blood and trap it inside. This is how an erection is formed. Thus, by expanding the blood vessels in the smooth muscle tissue of the penis, Silagra helps to attain and maintain an erection.

Will Silagra give me spontaneous erections?

According to its design, Silagra acts only in the presence of sexual stimulation. We have described how its active substance helps to form an erection, and you have seen that it acts on the level of signal transmission. This signal comes from the brain, but Silagra is not capable of instigating it: the brain sends the message to activate the erectile function only when the user is sexually aroused.

In practice though, many users of Silagra point out the powerful erectogenic effect of the drug that makes it extremely easy to achieve penile hardness following the slightest erotic stimulus. It should be stressed though that sildenafil has no direct effect on libido, it only improves the mechanics of sexual function.

How does Silagra act long-term?

With continued use, the response to Silagra improves. According to this study, it may take up to 8 doses administered on separate days to achieve the maximal health outcomes with sildenafil.

At the same time, the tolerability of sildenafil, too, becomes better over time, as clinically proven by Dr. Culley C Carson of the University of North Carolina School of Medicine.

The best part of using Silagra long-term is that the drug is capable of restoring the natural ability to achieve and maintain erections in non-medicated state: during this study, 60.4% of men were able to achieve erections a month after discontinuation of sildenafil therapy that had laster 12 months. However, full recovery from ED requires daily dosing with sildenafil.

Understandably, daily intake of Silagra will have to be approved by a doctor, and will entail considerable expenses. Read here how to minimize the cost of Silagra refills.

Sildenafil Side Effects, Contraindications, Interactions And Precautions

Sildenafil contraindications: when you should not take Silagra

Silagra is a safe drug with a long history of effective and trouble-free use. Sildenafil, the active component in Silagra, has proven itself to be well-tolerated, effective and usable in men of different age groups. How come that Silagra still is a non-recommended pill in some patients? Every drug has its contraindications which come from other diseases, hypersensitivity, incompatibility with other drugs, etc.

It is therefore your responsibility as a patient to inform your doctor about the medicines you currently use and your health history. Below we will list health conditions that make the use of Silagra dangerous. Avoid taking sildenafil if you have:

• Heart disease
• Leukemia
• Sickle cell disease
• Hemorrhage disorder
• Stomach ulcer
• Duodenum ulcer
• Peyronie’s disease
• Priapism
• NAION
• Angular glaucoma
• Retinitis pigmentosa
• Hypersensitivity to sildenafil
• Hypersensitivity to lactose
• Kidney failure
• Liver dysfunction

I take other drugs; can I take Silagra?

The answer to this question entirely depends on what kind of medications you are taking, and if you plan to take them alongside with Silagra or not. Fundamentally though, you need to discuss the drug compatibility with your prescriber. He or she will advise you how to use the medications together with maximal safety.

And yet, here is the list of drugs that absolutely should not be used alongside with Silagra. How do you tell which they are? Consult your doctor, the insert to the drug, keep our ”Generic Sildenafil – What You Need To Know” handy, or remember the drug classes to avoid when taking sildenafil:

Alpha-blockers	Doxazosin (Cardura), Prazosin (Minipress), Terazosin
Beta-blockers	Acebutolol (Sectral), Atenolol (Tenormin), Bisoprolol (Zebeta), Metoprolol (Lopressor, Toprol XL), Nadolol (Corgard), Nebivolol (Bystolic), Propranolol (Inderal, InnoPran XL)
Anti-fungals	Clotrimazole, Econazole, Miconazole, Terbinafine, Fluconazole, Ketoconazole, Amphotericin,
Anti-retrovirals	Abacavir (Ziagen), Didanosine (Videx), Emtricitabine (Emtriva), Lamivudine (Epivir), Stavudine (Zerit), Tenofovir alafenamide (Vemlidy), Tenofovir disoproxil fumarate (Viread), Zidovudine (Retrovir),
Nitrates	Nitroglycerine, Dinitrate, Isosorbide mononitrate

What side effects can Silagra cause?

The nature of Silagra side effects is:

• Short-lived
• Mild to moderate
• Manageable

What side effects to expect?

• Headache
• Flushing
• Digestive trouble
• Queasy stomach
• Nasal discharge problems

When to seek medical help?

• If adverse reactions are persistent or intense
• If you cannot breathe normally, have pain in the chest/arm, swelling of the face, abnormally prolonged or painful erection, or have a fainting episode

Silagra side effects management

This is how you avoid developing Silagra side effects: a) always follow doctor’s advice and read the insert carefully; b) take the drug after a light meal; c) avoid drinking alcohol at the moment of intake; d) do not increase the dose without doctor’s approval.

This is how you mitigate sildenafil side effects: a) continue taking Silagra – the side effects disappear with long-term use as your body adjusts to sildenafil; b) discuss a reasonable reduction in dose with your prescriber.

Silagra (Generic Sildenafil) And Alcohol

The psychology behind the use of alcohol alongside with ED drugs

Alcohol indeed helps to overcome shyness or strengthen sexual arousal thanks to the lifting of the brakes that it operates. It also makes it possible to forget fears or to extinguish the mind and consciousness. It is therefore hardly surprising that one wants to wash down his anxiety linked to sexual performance with a glass of wine, or possibly something stronger, followed by a tablet of Silagra or another ED drug. This is not the best idea, and this article explains why.

Why do we associate alcohol with romance? Alcohol has an aphrodisiac role – in small doses! Who has not realized that a glass of wine uninhibits and distresses? Alcohol frees the shy, gives confidence and daring. Unleash the fantasies and make you feel sexier. It still makes one believe in sexual omnipotence. But beware, these effects only work if you limit the amount of alcohol ingested. After a certain number of drinks – this number varies according to your gender and your body mass – alcohol tends to be a buzzkill due to its harmful effects on sexuality.

The dangers of combined use of Silagra and alcohol

While Silagra produces an excellent therapeutic effect on the mechanism behind erection, it does not generate sexual desire. Alcohol works the other way around: it gives libido a boost but puts a damper on erectile capacity. To some, combining Silagra and alcohol might appear like a win-win deal, but it is not.

The fact is, sildenafil contained in Silagra acts on the level of blood vessels. It blocks the enzyme that regulates blood vessel rigidity (PDE5) and promotes dilation of the blood vessels. The improved blood circulation in the penis creates the tension that your body needs to achieve and maintain an erection.
At the same time, a mild effect on your blood pressure is exerted by sildenafil. Alcohol, too, has these hypotensive effects on the blood pressure. As a result, both substances used together can sometimes provoke a dangerous and sudden drop in blood pressure, and both of them will be metabolized by the liver, creating an unnecessary strain on your excretory system.

At the same time, the study carried out by the researches of Centre for Cardiovascular Science, The University of Edinburgh suggests that the use of sildenafil with moderate quantities of red wine has no measurable effects on the blood pressure. The conclusion would be, use alcohol with moderation if you must, and it best not be anything harder than wine.

Moderate alcohol consumption

For safe use of Silagra with alcohol, drink alcohol in moderation. We hear this a lot, but what does it actually mean? According to sildenafil developer, 4 units of alcohol is a safe amount to be taken alongside with the drug. We refer to the infographics below to check the content of alcohol in various drinks.